Weight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. The effect of ...

Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking ...

Patients with IgA nephropathy and severe proteinuria have a high lifetime risk of kidney failure. The efficacy and safety of the selective endothelin type A receptor antagonist atrasentan in ...

In the active trial, patients with chronic kidney disease were randomly assigned to receive either empagliflozin (10 mg once daily) or matching placebo and were followed for a median of 2 years ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double ...

Mark Wicclair is an adjunct professor of medicine at the University of Pittsburgh Center for Bioethics and Health Law and a professor of philosophy emeritus at West Virginia University. Stephen ...