Weight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. The effect of ...

Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking ...

There is growing concern about the well-being of physicians and the consequences of poor well-being for physicians themselves, their patients, and the broader health care system. Diminished well ...

The heterogeneous clinical presentation of graft microvascular inflammation poses a major challenge to successful kidney transplantation. The effect of microvascular inflammation on allograft ...

Hereditary angioedema is a rare genetic disease characterized by severe and unpredictable swelling attacks. NTLA-2002 is an in vivo gene-editing therapy that is based on clustered regularly ...

Patients with IgA nephropathy and severe proteinuria have a high lifetime risk of kidney failure. The efficacy and safety of the selective endothelin type A receptor antagonist atrasentan in ...

Hairy-cell leukemia (HCL) is a rare, indolent neoplasm of mature B cells with hairlike surface projections that circulate in the blood and preferentially infiltrate the bone marrow and spleen.

Dr. Beatriz Rizkallah Alves (Neurology): A 71-year-old woman was transferred to this hospital for neurosurgical evaluation because of confusion, aphasia, and a mass lesion in the brain. The ...

In the active trial, patients with chronic kidney disease were randomly assigned to receive either empagliflozin (10 mg once daily) or matching placebo and were followed for a median of 2 years ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double ...

As limits on access to gender-transition–related health care increase, it’s helpful to contextualize the shift in terms of historical characterizations and fears of sexual and gender minority ...

Therapies are needed for patients with heart failure with mildly reduced or preserved ejection fraction. New research findings on the nonsteroidal mineralocorticoid receptor antagonist finerenone ...