SportsLine reveals its projected leaderboard for the 2025 Brickyard 400 and the championship round of the NASCAR In-Season Challenge. Use it for NASCAR picks at sites like DraftKings, FanDuel and PrizePicks.

The NASCAR Cup Series returns to Indianapolis Motor Speedway for the second consecutive year after a three-season layoff. The green flag drops on the Brickyard 400 at IMS at 2 p.m. ET. Kyle Larson is the defending champion of this event and is one of the top betting favorites to win the race.

This Sunday's Brickyard 400 presented by PPG isn't just a chance for Denny Hamlin to go back-to-bac for the second time this season in the NASCAR Cup Series. It

On one side, they'll monitor whether Kyle Larson can defend his Brickyard 400 title or if Denny Hamlin can charge from the back of the field to become the fifth driver to complete a career sweep of the Cup's four crown jewel races.

Denny Hamlin heads into Indianapolis with his eyes set on a second consecutive win, fresh off his Dover triumph. While he has already become the first driver this year to bag four Cup wins, a Brickyard 400 win would carry a weight far greater than all four combined to him.

Kyle Larson, the defending Brickyard oval winner, also profiles as a top contender in strong equipment and with proven speed at IMS. William Byron, tied for favoritism in some books, enters with solid speed and a big-season Daytona 500 win, but uneven recent form clouds his Brickyard upside.

Kyle Larson and Denny Hamlin open as favorites for NASCAR's Brickyard 400. Check out the early odds for the entire field.