The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

To dissect functional, transcriptional, and metabolic effects, hearts and isolated ventricular myocytes from mice harboring a moderate, cardiac-specific expression of a human ADRB3 transgene (β3AR-Tg) ...

Yet when “naked” RNA is injected, it degrades quickly. To address this issue, scientists have developed, and now widely use, the strategy of encapsulating mRNA into lipid nanoparticles (LNPs).

Precursor to DNA and RNA, used as a coenzyme. Vector phosphate stock illustrations. Coenzyme A, chemical formula and skeletal structure. Adenosine triphosphate, ATP, chemical formula and skeletal ...

Although the cellular immune response controls metabolism to try to limit viral infection, the mechanisms involved remain poorly understood. This study identifies the antiviral effector RNA-activated ...

Phosphate, a compound critical to the formation of RNA, abounds in record-setting levels in Last Chance Lake. Credit: David C. Catling Life’s first toehold on Earth was likely in a watery place ...

More recently, the H-phosphonate chemistry has found applications in the synthesis of DNA and RNA analogs including: (i) boranealkylphosphines (Roy and Caruthers, 2013), boranephosphonates and ...

In recent years, nucleic acid has emerged as a versatile molecule that has been strategically used in material synthesis and biomedical applications. Keeping in mind the presence of the phosphate ...

Buck, H. (2023) The Biochemical Impact by Covalent Shielding of the Anionic Oxygen of the Phosphate Group in DNA and RNA as Methylated Phosphotriester Linkage on the Inhibition of DNA Duplication and ...

RNA or ribonucleic acid is a polymer of nucleotides that is made up of a ribose sugar, a phosphate, and bases such as adenine, guanine, cytosine, and uracil. It plays a crucial role in gene ...