Scientists have discovered how a key protein helps maintain strong connections between brain cells that are crucial for ...

Parkinson’s disease is the second most prevalent neurodegenerative disease and presents a global health challenge. About 90,000 people are diagnosed in the US every year. About 10 million people world ...

Data suggest that “venetoclax usage should be avoided in the general relapsed or refractory multiple myeloma population,” the researchers wrote.

The Food and Drug Administration (FDA) has granted accelerated approval to Lynozyfic™ (linvoseltamab-gcpt) for the treatment of adult patients with ...

The FDA approved Lynozyfic (linvoseltamab-gcpt) to treat adults with relapsed/refractory multiple myeloma who have received at least 4 prior lines of therapy.

Regeneron Pharmaceuticals, Inc. REGN obtained FDA approval for linvoseltamab-gcpt for the treatment of relapsed or refractory ...

Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that the U.S. Food and Drug Administration (FDA) has granted accelerated approval for Lynozyfic™ (linvoseltamab-gcpt) to treat adult ...

The new project, called Sizewell C, will be expensive to build, but it will create 10,000 jobs and provide a steady supply of electric power for millions of homes.

Here, we present an approach named ProteasomeID that enables the quantification of proteasome interacting proteins and substrates in cultured human cells and mouse models. The approach entails fusing ...

These regulators open the 20S proteasome gate and enhance the complex’s catalytic activity. Alternatively, ubiquitin and ATP-dependent degradation of folded substrates is executed by the 26S and 30S ...

The 20S particle can be associated with 1 or 2 19S regulatory particles, forming a 26S proteasome. To date, a number of posttranslational modifications of 26S proteasome subunits have been reported, ...

New research has discovered that the 19S proteasome particle, typically associated with protein degradation in the brain, can function independently in synapses, regulating key synaptic proteins and ...