Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking ...

Patients with IgA nephropathy and severe proteinuria have a high lifetime risk of kidney failure. The efficacy and safety of the selective endothelin type A receptor antagonist atrasentan in ...

In the active trial, patients with chronic kidney disease were randomly assigned to receive either empagliflozin (10 mg once daily) or matching placebo and were followed for a median of 2 years ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double ...

Mark Wicclair is an adjunct professor of medicine at the University of Pittsburgh Center for Bioethics and Health Law and a professor of philosophy emeritus at West Virginia University. Stephen ...

The heterogeneous clinical presentation of graft microvascular inflammation poses a major challenge to successful kidney transplantation. The effect of microvascular inflammation on allograft ...

Hereditary angioedema is a rare genetic disease characterized by severe and unpredictable swelling attacks. NTLA-2002 is an in vivo gene-editing therapy that is based on clustered regularly ...

Therapies are needed for patients with heart failure with mildly reduced or preserved ejection fraction. New research findings on the nonsteroidal mineralocorticoid receptor antagonist finerenone ...

What is known about the use of steroidal mineralocorticoid receptor antagonists in patients with heart failure and mildly reduced or preserved ejection fraction? Steroidal mineralocorticoid ...

There is growing concern about the well-being of physicians and the consequences of poor well-being for physicians themselves, their patients, and the broader health care system. Diminished well ...

Dr. Beatriz Rizkallah Alves (Neurology): A 71-year-old woman was transferred to this hospital for neurosurgical evaluation because of confusion, aphasia, and a mass lesion in the brain. The ...

As limits on access to gender-transition–related health care increase, it’s helpful to contextualize the shift in terms of historical characterizations and fears of sexual and gender minority ...