Overall, this fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. The evidence supporting the ...

When propagated in cell lines, certain viruses acquire positively charged amino acids on their surface proteins, enabling them to utilize negatively charged heparan sulfate (HS) as an attachment ...

Activator of G-protein signaling C-terminus serves as a variable element to induce asymmetric cell division, facilitating developmental diversity among species.

Breast cancer cells exhibit organotropism during metastasis, showing preferential homing to certain organs such as bone, lung, liver, and brain. One potential explanation for this organotropic ...

This study provides important insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and highlights the ...

For the organism it is important to replenish internal energy storages selectively and selective appetite for nutrients might uncover internal energy requirements. How is the selective uptake of a ...

The location of a point in a two-dimensional space can be defined by Cartesian coordinates that indicate its position relative to horizontal and vertical axes. This system was introduced in the 17 th ...

Valencia et al. combine elegant in vitro biochemical experiments with functional assays in cardiomyocytes to determine which properties of the FHOD3 formin are essential for sarcomere assembly. Using ...

Measuring mitochondrial respiration in frozen tissue samples provides the first comprehensive atlas of how aging affects mitochondrial function in mice.

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, USA Department of Microbiology, UMass Chan Medical School, , USA ...

During parasitoid wasp infection, activated immune cells of Drosophila melanogaster larvae release adenosine to conserve nutrients for immune response. S-adenosylmethionine (SAM) is a methyl group ...

This study investigates the fundamental role of polyunsaturated fatty acids (PUFAs) in membrane biology, using a unique model to perform a thorough genetic screen that highlights that PUFA synthesis ...