In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

Every living cell must interpret its genetic code - a sequence of chemical letters that governs countless cellular functions.

Fully cell-free process aims to democratize personalized cancer therapeutics with shorter turnaround and negligible bioburden ...

DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

There are large differences between the intracellular environment and the conditions widely used to study RNA structure and function in vitro. To assess the effects of the crowded cellular environment ...

A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.

Modeling the structure and dynamics of large macromolecules remains a critical challenge. Molecular dynamics (MD) simulations are expensive because they model every atom independently, and are ...

RECENTLY many viruses belonging to different varieties of groups have been identified as having anomalous structures of nucleic acid, including a double-stranded structure of RNA in reoviruses and ...

HiCapR uncovers HIV RNA homodimers and long-range interactions that show structural dynamics critical for viral packaging and assembly.

The prediction of RNA three-dimensional structure from sequence alone has been a long-standing goal. High-resolution, experimentally determined structures of simple noncanonical pairings and motifs ...

Williams, W.R. (2018) Cell Signal Transduction Hormones, Neurotransmitters and Therapeutic Drugs Relate to Purine Nucleotide Structure. Journal of Receptors and Signal Transduction, 38, 101-111.