The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part ...

In fact, the study revealed that the proteasome itself constantly produces these peptides as part of its routine activity, and that this production ramps up significantly during bacterial infections. ...

Much like humans generate mountains of garbage, our cells are constantly discarding proteins that are damaged or no longer needed. The cellular waste disposal system called the proteasome is best ...

Proteasome phase separation for destruction. Tokyo Metropolitan Institute of Medical Science. Journal Nature DOI 10.1038/s41586-020-1982-9 ...

Scientists have long known that the cells’ ‘protein destruction machine’, the proteasome, plays a crucial role in protein clearance within the brain. However, a new study published in ...

Activation of the 20S proteasome requires the binding of regulatory proteins such as the 19S regulatory particle, which opens the 20S gates allowing substrate access to the active sites. New data ...