Embryos from women with PCOS carry changes in how their genes work, which may help explain why the condition runs in families ...

Histone deacetylases (HDACs) are a class of epigenetic enzymes that remove acetyl groups from lysine residues on histones and other proteins. In this Review, the authors highlight the role of ...

histone / histones Supercoiled DNA wrapped around histone proteins (red). Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin.

Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation that is greater in patients with advanced disease. We asked whether there is a link between the severity ...

Researchers continue to find new chemical modifications on the proteins our genes are wrapped around. Why are they there?

A recent review by Prof. Zhu Bing and Associate Professor Xiong Jun from the Institute of Biophysics of the Chinese Academy ...

Researchers have completed a comprehensive analysis of cancer-associated histone mutations in the human genome, featuring both biochemical and cellular characterizations of these substrates. Their ...

The discovery of this demethylase supports the long-held supposition that histone methylation is reversible, just as histone phosphorylation and acetylation are, Shilatifard points out.

Histone modification important for correct blood cell formation Date: December 18, 2024 Source: Ludwig-Maximilians-Universität München Summary: Molecular biologists decode the epigenetic ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role in understanding the complex interplay between genetics and the environment ...

Cell identity is preserved during DNA replication by a histone allocation mechanism that involves a replisome component called Mrc1 ...