This Sounding Board announces a new FDA policy that the default requirement for FDA approvals will be one robust pivotal trial plus confirmatory evidence, rather than two trials.

Exercise rehabilitation has a long history in the management of chronic heart failure, with the first randomized trial of exercise training dating back to 1990 1 — and by the late 1990s, it had become ...

A 91-year-old man was admitted to the hospital with weight loss, dyspnea, and eosinophilia. An anteroposterior chest radiograph obtained 2 months earlier showed bibasilar patchy opacities. A ...

Beyond being a rare federal program focused on stabilizing rural health care services, the Rural Health Transformation Program represents a vehicle for advancing the administration’s health priorities ...

Explore the current issue of The New England Journal of Medicine (Vol. 394 No. 7).

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 21).

A 60-year-old man presented with a 15-day history of generalized weakness and right upper abdominal pain. Imaging studies revealed diffuse disruption of the hepatic architecture by hyperechoic nodules ...

Mucormycosis is a rapidly progressive, invasive fungal infection that affects patients who are severely immunocompromised, as well as patients with diabetes and persons with immunocompetence who have ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 13).

A high-school wrestler presented with an itchy rash that had worsened despite topical antifungal and glucocorticoid treatment. A circular, scaly plaque with papules, nodules, and pustules was seen ...

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 10).

Abstract To the Editor: We would like to address two potentially confusing issues concerning venous oxygen saturation (Svo 2) as presented in Table 1 of the review by Angus and van der Poll (Aug. 29 ...