BMJ8d
Evidence that autoantibody production may be driven by acute Epstein-Barr virus infection in Sjögren’s disease
Objectives Sjögren’s disease (SD) is an autoimmune disease affecting the exocrine glands that is associated with autoantibodies against Ro60/SS-A, anti-Ro52/TRIM21, La/SS-B and others. We examined the ...
BMJ6d
Vascular occlusion for optimising the functional improvement in patients with knee osteoarthritis: a randomised controlled trial
Objectives Knee osteoarthritis (KOA) is a leading cause of global disability with conventional exercise yielding only modest improvements. Here we aimed to investigate the benefits of integrating ...
BMJ2d
LBA0001 EFFICACY AND SAFETY OF UPADACITINIB IN PATIENTS WITH GIANT CELL ARTERITIS (SELECT-GCA): A DOUBLE-BLIND, RANDOMIZED CONTROLLED PHASE 3 TRIAL
11 University of Pennsylvania, Division of Epidemiology, Department of Biostatistics, Epidemiology, and Informatics, Philadelphia, PA, United States of America 12 University of Pennsylvania, Division ...
BMJ5d
Treatment efficacy and safety of tofacitinib versus methotrexate in Takayasu arteritis: a prospective observational study
Objective To compare the treatment efficacy and safety of tofacitinib (TOF) versus methotrexate (MTX) in Takayasu arteritis (TAK). Methods Fifty-three patients with active disease from an ongoing ...
BMJ3d
Nucleation of monosodium urate crystals.
(1) Calcium greatly increased crystallization of monosodium urate in otherwise pure water, by enhancing both nucleation and growth. (2) Acid accelerated urate nucleation, both by its direct action and ...
BMJ12d
EULAR recommendations for the management of systemic lupus erythematosus: 2023 update
Correspondence to Dr Dimitrios T Boumpas, Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, "Attikon" University Hospital, Joint Academic Rheumatology Program, National ...
BMJ4d
It is time to rethink juvenile idiopathic arthritis classification and nomenclature
Correspondence to Alberto Martini, University of Genoa, Pediatria II, Istituto G Gaslini, Largo Gaslini 5, Genova 16147, Italy; albertomartini{at}ospedale-gaslini.ge.it Juvenile idiopathic arthritis ...
BMJ11d
Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study
1 Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands 2 Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands 3 Institute of Anatomy ...
BMJ8d
Management of systemic lupus erythematosus: a systematic literature review informing the 2023 update of the EULAR recommendations
Objectives To analyse the new evidence (2018–2022) for the management of systemic lupus erythematosus (SLE) to inform the 2023 update of the European League Against Rheumatism (EULAR) recommendations.
BMJ5d
Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis
Objectives Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis (OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a novel vaccine strategy ...
BMJ5d
Cytokine levels in human synovial fluid during the different stages of acute gout: role of transforming growth factor β1 in the resolution phase
Methods SFs from 38 gouty patients were analysed for white blood cell (WBC) count, percentage of polymorphonuclear cells (PMNs) and levels of interleukin 1β (IL-1β), IL-6, IL-8, tumour necrosis ...
BMJ5d
Severity and extent of osteoarthritis and low grade systemic inflammation as assessed by high sensitivity C reactive protein
2 Department of Orthopaedic Surgery (RKU), University of Ulm, Germany 3 Department of Internal Medicine II—Cardiology, University of Ulm, Germany Correspondence to: Dr T Stürmer Department of ...