Deebo Samuel fantasy managers are in a tricky position Sunday as the wide receiver works his way back from an illness and wrist injury in the same week the San Francisco 49ers play on Sunday Night Football.

In addition to Aiyuk, the 49ers will be short wide receiver Jauan Jennings, defensive linesman Kevin Givens, and kicker Jake Moody. At this point in the season, San Francisco is currently at 3-4, so they could use a boost of any kind, even if it just means having fewer players injured this time around.

Deebo Samuel was injured in the fourth quarter of the 49ers' Week 8 game, and head coach Kyle Shanahan was uncertain of the severity.