a process tightly controlled by the unfolded protein response (UPR). New research published in eGastroenterology demonstrates that disruptions in the UPR contribute to inflammatory bowel diseases ...

a process tightly controlled by the unfolded protein response (UPR). New research published in eGastroenterology demonstrates that disruptions in the UPR contribute to inflammatory bowel diseases ...

A detailed quantitative model of signaling by IRE1 sheds light on the mechanism of its activation by endoplasmic reticulum stress and addresses a long-standing controversy in the field. In ...

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions. This folding process occasionally goes awry, resulting in misfolded proteins ...

Solute carrier family 26 member 2 (SLC26A2) is an SO42− transporter, facilitating the uptake of inorganic sulfate into cells. Mutations in SLC26A2 lead to chondrodysplasia, a rare genetic disorder ...

Under stress, mitochondria rapidly increase their copy number—that is, the number of mitochondrial genomes in each organelle—as part of a process called the mitochondrial unfolded protein response, or ...