a process tightly controlled by the unfolded protein response (UPR). New research published in eGastroenterology demonstrates that disruptions in the UPR contribute to inflammatory bowel diseases ...

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions.

a process tightly controlled by the unfolded protein response (UPR). New research published in eGastroenterology demonstrates that disruptions in the UPR contribute to inflammatory bowel diseases ...

A detailed quantitative model of signaling by IRE1 sheds light on the mechanism of its activation by endoplasmic reticulum stress and addresses a long-standing controversy in the field. In ...

Solute carrier family 26 member 2 (SLC26A2) is an SO42− transporter, facilitating the uptake of inorganic sulfate into cells.

Under stress, mitochondria rapidly increase their copy number—that is, the number of mitochondrial genomes in each organelle—as part of a process called the mitochondrial unfolded protein response, or ...

Control of protein folding and mis-folding in vivo: recognition of unfolded protein, the UPR or unfolded protein response, proteostasis, and the role of the ubiquitin-proteasome system.