Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are ...
A topoisomerase enzyme discovered more than a decade ago in an archaeal microorganism turns out to be distinct, both structurally and mechanistically, from any other known topoisomerase. Only four ...
The development of DNA sensor systems is of great importance for advances in medical science. Now another piece of the puzzle for the development of personalized medicine has been found with the ...
Why do cancer patients develop resistance to chemotherapy drugs, sometimes abruptly, after a period in which the drugs seem to be working well to reduce tumors or hold them in check? Although largely ...
Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at the University of Seville in CABIMER) and with PharmaMAR, has identified ...
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