In this protocol extension, the authors detail an in-cell version of their previous in vitro SHAPE-MaP protocol, enabling RNA structure to be probed in living cells. This protocol is an extension ...

SCOPER has simplified it significantly. Say you want to study a new RNA: First, put the nucleotide sequence into one of the open-source, AI-based structure prediction tools available today.

DNA is fundamental to the biology of all life on Earth, but how many of us actually know what it is or what it's made of?

RNA Structure “ROCKs” at Near-Atomic Resolution. May 4, 2022. ... “The RNA’s core is resolved at 2.85 Å, revealing detailed features of the nucleotide bases and sugar backbone.

To understand the function of an RNA molecule, similar to the better-known DNA and vital for cell metabolism, we need to know its three-dimensional structure. Unfortunately, establishing the shape ...

New app shows 2-D structure of thousands of RNA molecules Date: September 2, 2010 Source: Stanford University Medical Center Summary: For the first time, it's possible to experimentally capture a ...

“But many RNA molecules take over cellular functions.” Their spatial structure is important for this. Similar regions in a nucleotide sequence can cluster together to form three-dimensional ...

Scientists described how to decipher RNA secondary structure via novel mathematic approaches or via in-gel analysis ... a ~350 nucleotide RNA segment necessary for export of full-length and ...