Heart failure has increasingly been recognized as a complex, metabolism-driven syndrome that extends far beyond traditional models of hemodynamic ...
G protein-coupled receptor kinase 2 (GRK2) has emerged as a pivotal regulator in the pathophysiology of heart failure. GRK2 mediates the phosphorylation of activated G protein‐coupled receptors (GPCRs ...
This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...
The SGLT2 inhibitor medicines have changed how heart failure is managed. Originally sodium-glucose cotransporter 2 (SGLT2) inhibitors were used to lower blood sugar levels in people who have type 2 ...
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What Causes Congestive Heart Failure?
High blood pressure causes your heart's walls to thicken, which increases your risk of congestive heart failure (CHF). Coronary artery disease decreases blood flow and can weaken your heart over time.
Nonischemic cardiomyopathy is when problems with your heart muscle aren’t due to reduced blood flow. Instead, causes include genetics, infections, and autoimmune conditions. Cardiomyopathy is the ...
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