Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disease due to a genetic defect, where your red blood cells (RBCs) do not have a protective layer of proteins. These missing proteins cause ...

If you have PNH, you will find that your condition requires constant management. But it’s important to be able to confront it head-on. If you do this, you will be better able to manage your symptoms ...

Clone size and symptom burden dictate how often patients with PNH require follow-up. Hematology assessments during routine visits should include flow cytometry, CBC, D-dimer levels, and serum ferritin ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder that causes red blood cells to break down. This can lead to symptoms and complications ranging from discoloration of urine to leukemia and ...

Paroxysmal nocturnal hemoglobinuria leaves red blood cells more vulnerable to destruction. A common side effect is blood clots, known as thrombosis. This is largely preventable with medication to ...

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired, potentially life-threatening disorder. It causes the red blood cells to break apart, a process called hemolysis. This releases hemoglobin from ...

A novel, single tube, multi-parameter 7-color immunophenotyping assay was developed to characterize PNH clones in blood leukocytes. Monocytes, eosinophils and basophils had the highest proportion of ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disease in which the immune system breaks apart the red blood cells (RBCs) in the body. The medical term for this premature rupture of RBCs is ...

Iptacopan demonstrated significant hemoglobin improvements in PNH patients transitioning from anti-C5 therapies, validating its efficacy as an oral monotherapy. The safety profile of iptacopan was ...