DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

Acetylation of histone H3 at the nucleosome surface is associated with destabilised nucleosomes and is a useful new functional genomics mark for identifying regulatory regions of the mammalian genome.

Illustration of H2B or H3 tail-less nucleosomes. Nucleosomes lacking H2B and H3 tails exhibit weakened interactions between histone tails and nucleosomal DNA, leading to less stable nucleosome ...

Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers-about a millionth of a milliliter. The cell manages this by ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...