Figure 1: Co-agonist stimulation induces dynamin-dependent NMDA receptor internalization. Figure 2: Glycine site stimulation initiates a progressive decline in NMDA receptor-mediated currents. Figure ...

The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is ...

Structural biologists at Cold Spring Harbor Laboratory (CSHL) and collaborators at Emory University have obtained important scientific results likely to advance efforts to develop new drugs targeting ...

Gainesville, FL - Temporal summation of repeated pain stimuli, also known as "windup" pain, is mediated by N-methyl-D-aspartate (NMDA) receptors, and this pathway has long been suspected of ...

Surgery was performed as described (Basselin et al, 2003; Chang et al, 1996). A rat was wrapped loosely in a fast-setting plaster cast taped to a wooden block, and allowed to recover from anesthesia ...

Researchers have obtained images of the NMDA receptor in active, non-active, and inhibited states. Understanding how NMDA receptors activate is critical in designing novel therapeutic compounds for ...

A new study suggests a potential molecular strategy for treating fragile X syndrome, an inherited neurodevelopmental disorder that causes autism spectrum disorder and intellectual disability. This ...

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

October 20, 2008 – Tumor removal and immunotherapy can reverse anti-NMDA–receptor encephalitis, researchers show. Reporting in an early release published online October 11 in Lancet Neurology, ...

With the ink barely dry on a partnership deal with Allergan, Aptinyx has announced plans for an $80 million IPO to accelerate work on its drugs for neurological disorders. The Evanston, Illinois-based ...