In the absence of their cognate ligand, dependence receptors trigger programmed cell death. This function is the defining feature of dependence receptors, which include members of several different ...

Researchers at Tampere University, Finland, have published new results in collaboration with an international research network that help to understand the biological phenomena mediated by cell ...

Beta-1 integrin, a critical component of epithelial extracellular matrix receptors, is essential for normal lung function in adulthood, researchers at Vanderbilt University Medical Center have ...

Globally, human hepatocellular carcinoma (HCC) is the sixth most common cancer and the fourth leading cause of cancer-related mortality. The worldwide incidences of HCC have been on the rise in recent ...

New data show that integrin signaling by the Syk tyrosine kinase requires adaptors, such as DAP12, that have immunoreceptor tyrosine-based activation motifs. Intimately connected to the issue of how ...

Researchers from the US and China summarize the role of integrins in cancer cells and the current status of anti-integrin therapy for cancer Globally, human hepatocellular carcinoma (HCC) is the sixth ...

Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...