Bromodomain-containing protein 7 (BRD7) was initially identified as a tumor suppressor, but further research has shown it has a broader role in other cellular processes, including the remodeling of ...

In 2021, a research team discovered the insulin-inhibitory receptor 'Inceptor' and its role as a suppressor of the insulin signaling pathway. Now, the researchers have unlocked another, even more ...

Insulin plays a central role in coordinating renal glucose handling by modulating both reabsorptive and synthetic processes in the nephron. In the proximal tubule, insulin binding to its receptor ...

Developing resistance to insulin is a key step on the road to diabetes, making insulin resistance a target for treating metabolic dysfunction. Insulin orchestrates blood glucose levels by signaling ...

McGill University researchers have identified a brain function that helps explain why childhood stress raises metabolic health risks for some women later in life. A new study found that variations in ...

Adrenomedullin, a hormone first identified in an adrenal medullary tumor, disrupts the effect of insulin on the endothelium of blood vessels, leading to insulin resistance linked to obesity and type 2 ...

“Although the detailed mechanism for the stimulation of intra-islet GLP-1 secretion remains to be elucidated and further studies are required, as far as we know, our present study is the first to ...

Study: Personalized molecular signatures of insulin resistance and type 2 diabetes. Image credit: Microgen/Shutterstock.com A recent study, published in the journal Cell, utilized cutting-edge ...

Investigators at the Helmholtz Institute have shown that inceptor, an inhibitor of the insulin signaling pathway, acted by binding insulin and targeting it for degradation. “Insulin was discovered 100 ...

Overview of peripheral and central insulin actions (black arrows). The vast majority of insulin hormones are synthesized by the pancreas. Insulin crosses the blood‒brain barrier (BBB) to act within ...

Progressive Adipokine Depletion: Investigators observed that median serum omentin-1 significantly dropped as body weight ...