Histone deacetylases (HDACs) are a class of epigenetic enzymes that remove acetyl groups from lysine residues on histones and other proteins. In this Review, the authors highlight the role of ...

Embryos from women with PCOS carry changes in how their genes work, which may help explain why the condition runs in families ...

Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, ...

For example, if a histone protein has 10 modification sites, bottom-up proteomics can tell you that those modifications exist but not whether all 10 are on the same histone at the same time.

Increases in histone acetylation are usually associated with gene induction. 6,7 The overall acetylation status of histones depends on the dynamic equilibrium between HAT activity and HDAC activity.

In total, 11 abstracts on givinostat were accepted for presentation at the Congress, including two for an oral presentation ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

During therapy, some cancer cells evolve to escape elimination. Newer anticancer drugs that can overcome this resistance are ...

Histone mutational landscape of human cancers Date: March 1, 2021 Source: Princeton University Summary: Researchers have completed a comprehensive analysis of cancer-associated histone mutations ...

So-called histone methyltransferases "also methylate a broad range of other protein substrates," Coonrod explains, noting that arginine methylation is a particularly widespread modification.

Graphical abstract from “The fork protection complex promotes parental histone recycling and epigenetic memory” [Charlton et al. Cell 2024; DOI: 10.1016/j.cell.2024.07.017].

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers. Proceedings of the National Academy of Sciences , 2024; 121 (52) DOI: 10.1073 ...