A global collaboration agreement has been signed for the development and commercialization of a Granzyme B-targeted Positron Emission Tomography (PET) imaging radiotracer. This radiotracer has the ...

A newly developed imaging method, granzyme B PET, can non-invasively detect inflammatory bowel disease (IBD) and provide a real-time picture of active inflammation in the tissue, according to new ...

Cellular parasites have evolved clever anti-apoptosis strategies to avoid being killed by CTLs. However, CTL release of granzyme A inactivates a key repair enzyme, Ape1, ensuring death of infected ...

Stability and toxicity are two of the major challenges. First, linker stability issues result in the immediate release of the drug payload following administration, which results in persistent high ...

SUDBURY, Mass.--(BUSINESS WIRE)--CytoSite Bio, a company developing precision imaging products that determine patient response to immuno-oncology therapy today shared new data at the Radiological ...

When killer T cells of the immune system encounter virus-infected or cancer cells, they unload a lethal mix of toxic proteins that trigger the target cells to self-destruct. A new study shows T cells ...

Harvard Medical School scientists have identified a key protein in the human immune system that drives inflammatory and autoimmune conditions when it turns against the body. The protein, Granzyme K, ...

Granzyme B is a serine protease of the chymotrypsin fold that mediates cell death by cytotoxic lymphocytes. It is a processing enzyme, requiring extended peptide substrates containing an Asp residue.

Researchers also found that the amount of granzyme protein present in joint tissue correlated with the severity of the disease, often measured as joint inflammation. This correlation was independent ...

Visual Abstract. Active bowel inflammation disrupts the bowel cell lining, which causes the inflammatory T cells to secrete Granzyme B into the extracellular space, progressively accentuating the ...