THE measurement of the dihydroxycholanic acids found in human bile (chenodeoxycholic acid, 3α,7α-dihydroxycholanic acid and deoxycholic acid, 3α,12α-dihydroxycholanic acid) or of their ester ...

Postoperative adjuvant donafenib-based therapy for patients with hepatocellular carcinoma at high risk of recurrence. A retrospective study of donafenib with or without TACE as postoperative adjuvant ...

The FDA on Friday approved chenodiol (Ctexli) for the treatment of cerebrotendinous xanthomatosis (CTX) in adults. Chenodiol -- a naturally occurring human bile acid also known as chenodeoxycholic ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

Ursodeoxycholic acid (UDCA) is a secondary bile acid, which means that it is a bacterial metabolite of primary bile acids produced in the liver. It is a C7 epimer of chenodeoxycholic acid, one of the ...

Obeticholic acid (OCA) is a semisynthetic bile acid that is analogous to the natural acid chenodeoxycholic acid (CDCA). One of the two primary bile acids produced in the human liver, CDCA is the most ...