Cell division and PLK1: a three-stage activation process. The PLK1 protein plays a central role in cell division, and its dysregulation is associated with numerous cancers. Howeve ...

The molecular choreography of DNA replication is a finely balanced process ensuring that genetic information is faithfully transmitted during cell division. Replication initiation begins with origin ...

Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists as part of a DNA-protein complex known as chromatin. For this purpose, the ...

DNA replication in eukaryotes is a highly orchestrated process that ensures precise genome duplication before cell division. Initiation occurs at multiple replication origins that are licensed in G1 ...

Viruses are known to use the genetic machinery of the human cells they invade to make copies of themselves. As part of the process, viruses leave behind remnants throughout the genetic material ...

For almost 60 years, scientists have tried to understand why DNA doesn't replicate wildly and uncontrollably every time a cell divides, which happens constantly. Without this process, we would die.

Researchers have found that the way DNA is packaged in cells can directly impact how fast DNA itself is copied during cell division. They discovered that DNA packaging sends signals through an unusual ...

Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within ...

A new study finds that when p53, one of the most important cancer-protecting genes, stops working, cells produce too much RNA ...

Our DNA is constantly being packed and unpacked. And there is a good reason for this: depending on its packing state, it performs different functions in the cell nucleus. For most of its life – this ...

A time-delay circuit enables precise control over the division of synthetic DNA droplets, which mimic biological Liquid-Liquid Phase Separation (LLPS) droplets found in cells. By utilizing a ...