Potent drugs like chemotherapy can be life-saving, but often with life-threatening side effects. Notably, they can be ...

It is often the case that affinity ligands and bioconjugation strategies must be optimized for each new preparation to maximize the binding properties of the targeted conjugates 14,15. To streamline ...

The functional groups participating in the reaction are inert to biologically active molecules, and reactive selectively with each other. The chemistry of the reaction must also be nontoxic to the ...

The 2022 Nobel Prize in chemistry was awarded to scientists Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for their development of click chemistry and bioorthogonal chemistry. These ...

To attach probes for imaging to biomolecules inside cells or organisms, chemists have developed so-called bioorthogonal reactions that don’t interfere with the biochemistry of the living things.

Please provide your email address to receive an email when new articles are posted on . It’s not often that a 2 a.m. phone call marks the highlight of someone’s career. That call notified Bertozzi, ...

Bioorthogonal reactions are a series of chemical reactions that occur in biological environments with high yields, selectivity, efficiency, and no side reactions. These reactions include ...

Bioorthogonal chemical reporters are small exogenous reporters which do not chemically modify the biomolecules they are tagged to. Their small size means they do not interfere with gene expression or ...

Carolyn Bertozzi of Stanford University, Morten Meldal of the University of Copenhagen, and K. Barry Sharpless of Scripps Research won the Nobel Prize in chemistry on Wednesday “for the development of ...