with IU1 enhanced not only proteasome activity but also autophagy activity simultaneously. We demonstrated that this synergistic mechanism could improve age-related muscle weakness in fruit flies ...

with IU1 enhanced not only proteasome activity but also autophagy activity simultaneously. We demonstrated that this synergistic mechanism could improve age-related muscle weakness in fruit flies ...

This inevitably raises the question of how autophagy substrates are selected. Ubiquitylation is a well-established signal for selective degradation by the proteasome and it is also important for ...