Willson Contreras hit a go-ahead home run in a four-run sixth inning and the St. Louis Cardinals beat the Pittsburgh Pirates 6-3 on Monday night for their third straight victory.

Preview the May 6 matchup between the Pittsburgh Pirates and St. Louis Cardinals with odds over/under, game spread, betting lines and more.

It is Monday, May 5, and the Pirates (12-23) are in St. Louis to take on the Cardinals (16-19). Carmen Mlodzinski is slated to take the mound for Pittsburgh against Miles Mikolas for St. Louis. Pittsburgh has lost four straight games and seven of the past eight,

Xander Bogaerts had two hits and three RBI to lead the San Diego Padres to a 4-0 victory over the host Pittsburgh Pirates on Sunday afternoon.

Preview the May 4 matchup between the Pittsburgh Pirates and San Diego Padres with odds over/under, game spread, betting lines and more.

Pregame analysis and predictions of the San Diego Padres vs. Pittsburgh Pirates MLB game to be played on May 4, 2025 on ESPN.