Houston, Michigan State and Auburn came up clutch, while Tennessee was a bully from the start in Sweet 16 action Friday night.

The Houston Cougars and Purdue Boilermakers face off Friday night in a Sweet 16 NCAA Tournament matchup in Indianapolis. Houston (32-4) is favored by 8.5 points, but Purdue (24-11) is playing close to home and is loaded with experience.

The No. 4 seed Purdue Boilermakers (24-11) and the No. 1 seed Houston Cougars (32-4) will meet on Friday in the NCAA Tournament Sweet 16.

SportsLine expert Micah Roberts has revealed his Purdue Boilermakers vs. Houston Cougars picks for the Sweet 16 of the 2025 NCAA Tournament on Friday

This year's March Madness Sweet 16 wraps up Friday with Houston vs. Purdue. Here are expert picks, predictions and how to watch the game:

No. 4 Purdue plays No. 1 Houston in the Sweet 16 round of the NCAA Men's Basketball Tournament. Follow the live blog for in-game updates throughout the night.

Quite simply, this is not the year of the Cinderella squad. The silver lining: The second-weekend matchups are loaded.

SportsLine's model revealed its college basketball predictions for Houston Cougars vs. Purdue Boilermakers on Friday in the Sweet 16 of the 2025 NCAA Tournament

Watch this Sweet 16 NCAA Tournament matchup between the No. 1 Houston Cougars (32-4) and No. 4 Purdue Boilermakers (24-11) to determine which of the squads is heading to the Midwest Region bracket