Cornerback Ja'Quan McMillian secures an interception off a deflection and returns the takeaway 45 yards for a Broncos touchdown.

An interception return for a touchdown by Broncos’ defensive back Ja’Quan McMillian was the difference in an inept offensive first half that has home team Denver leading the Justin Herbert-less Chargers, 10-3 at halftime on an incredibly warm first Sunday in January before an energized, sellout crowd at Empower Field at Mile High.

With Justin Herbert and most of the Chargers' starters not playing, the team puts in a strong defensive effort in a 19-3 loss to the Denver Broncos.

These are the players and plays that led to the Broncos' clinching win in the regular-season finale against the Chargers.

Denver Broncos vs. Los Angeles Chargers final score, results, analysis, stats from NFL Week 18 of 2025 regular season.

The Denver Broncos clinch the top seed in the AFC with their win over the Los Angeles Chargers in the season finale.

The Broncos are 14-point favorites in the latest Chargers vs. Broncos odds at DraftKings, and the over/under for total points scored is 37.5. Denver's over/under for total points scored is 26.5, while Los Angeles' is 10.

Broncos earn the No 1 seed in the AFC after beating the Chargers 19-3 while a Falcons win over the Saints pushed the Panthers through to the playoffs