But openers don’t always go as planned. Last season, when the Chiefs played their preseason opener at Jacksonville, Patrick Mahomes played the first series, leading the Chiefs to a field goal. Backup Carson Wentz entered the game for the second series, in the first quarter. Before halftime, then-third team quarterback Chris Oladokun led a drive.

Patrick Mahomes will take the field for the Kansas City Chiefs' preseason opener against the Arizona Cardinals on Saturday, but he won't have one of his top targets.